Scientific Publications

​Papers published in peer-reviewed journals.

Neurotransmitter uptake

  1. Marvizón, JCG, F. Mayor, Jr., MC Aragón, C. Giménez and F. Valdivieso. L-Aspartate transport into plasma membrane vesicles derived from rat brain synaptosomes. J. Neurochem. 37: 1401-1406, 1981.

  2. Mayor, F., Jr., JCG Marvizón, MC Aragón, C. Giménez, and F. Valdivieso. Glycine transport into plasma membrane vesicles derived from rat brain synaptosomes. Biochem. J. 198: 534-541, 1981.

  3. Aragón, MC, C. Giménez, F. Mayor, Jr., JCG Marvizón and F. Valdivieso. Tyrosine transport by membrane vesicles isolated from rat brain. Biochim. Biophys. Act 646: 465-470, 1981.

Neurotransmitter receptors: glycine, GABA, NMDA

  1. Marvizón, JCG, J. Vázquez, M. García Calvo, F. Mayor, Jr., A. Ruiz Gómez, F. Valdivieso, and J. Benavides. The glycine receptor: pharmacological studies and mathematical modeling of the allosteric interaction between the glycine- and the strychnine-binding sites. Mol. Pharmacol. 30: 590-597, 1986.

  2. Marvizón, JCG, M. García Calvo, J. Vázquez, F. Mayor, Jr., A. Ruiz Gómez, F. Valdivieso, and J. Benavides. Activation and inhibition of [3H]strychnine binding to the glycine receptor by Eccles' anions: modulatory effect of cations. Mol. Pharmacol. 30: 598-602, 1986.

  3. Marvizon, JCG and P. Skolnick. Enhancement of t-[35S]Butylbicyclophosphorothionate and [3H]strychnine binding by monovalent anions reveals similarities between g-aminobutyric acid- and glycine-gated chloride channels. J. Neurochem. 50: 1632-1639, 1988.

  4. Alonso, T., RO Morgan, JCG Marvizón, H. Zarbl, and E. Santos. Malignant transformation by ras and other oncogenes produces common alterations in phosphoinositide signaling pathways. proc. Nat. Acad. Sci. USA 85: 4271-4275, 1988.

  5. Marvizon, JCG and P. Skolnick. [3H]Glycine binding is modulated by Mg+2 and other ligands of the NMDA receptor-cation channel complex. Eur. J. Pharmacol. 151: 157-58, 1988.

  6. Marvizon, JCG and P. Skolnick. Anion regulation of [3H]strychnine binding to glycine-gated chloride channels is explained by the presence of two anion binding sites. Mol. Pharmacol. 34: 806-813, 1988.

  7. Marvizon, JCG, A. Lewin, and P. Skolnick. 1-Amino-cyclopropane carboxylic acid: a potent and selective ligand for the glycine modulatory site of the N-methyl-D-Aspartate receptor complex. J. Neurochem. 52: 992-994, 1989.

  8. Ruiz-Gómez, A., M. García-Calvo, J. Vázquez, JCG Marvizón, F. Valdivieso and F. Mayor, Jr. Thermodynamics of agonist and antagonist interaction with the strychnine-sensitive glycine receptor. J. Neurochem. 52: 1775-1780, 1989.

  9. Skolnick, P., JCG Marvizón, BW Jackson., JA Monn, KC Rice, and A. Lewin. Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropane-carboxylates. Life Sci. 45: 1647-1655, 1989.

  10. Marvizón, JCG, and P. Skolnick. An endogenous modulator of N-methyl-D-aspartate receptor-coupled glycine receptors. Eur. J. Pharmacol. Mol. Pharmacol. 188: 23-32, 1990.

  11. Ruiz-Gómez, A., C. Fernández-Shaw, E. Morato, JCG Marvizón, J. Vázquez, F. Valdivieso, F. Mayor, Jr. Sulfydryl groups modulate the allosteric interaction between glycine binding sites at the inhibitory glycine receptor. J. Neurochem. 56: 1690-1697, 1991.

  12. Shahi, K., JCG Marvizón and M. Baudry. High concentrations of glycine induce long-lasting changes in synaptic efficacy in rat hippocampal slices. Neurosci. Lett. 149: 185-188, 1993.

  13. Marvizón, JCG, and M. Baudry. NMDA receptor activation by spermine requires glutamate but not glycine. Eur. J. Pharmacol. Mol. Pharmacol. 244: 103-104, 1993.

  14. Lewin, AH, P. Skolnick, JCG Marvizón, IA Paul, and JP Bowen. Requirements for high affinity binding of glycine analogs to the glycine site of the NMDA receptor complex. Eur. J. Pharmacol. Mol. Pharmacol. 247: 1-10, 1993.

  15. Marvizón, JCG, and M. Baudry. Receptor activation by two agonists: Analysis by non-linear regression and application to N-methyl-D-aspartate receptors. Anal. Biochem 213: 3-11, 1993.

  16. Marvizón, JCG, and M. Baudry. [3H]Dizocilpine association kinetics distinguish stimulatory and inhibitory polyamine sites of N-Methyl-D-Aspartate receptors. J. Neurochem. 63: 963-971, 1994.

  17. Marvizón, JCG, and M. Baudry. Allosteric interactions and modulator requirement for NMDA receptor function. Eur. J. Pharmacol. Mol. Pharmacol. 269: 165-175, 1994.

Neuropeptides that control pain: substance P, endorphins, CGRP, BDNF

  1. Marvizón, JCG, V. Martínez, EF Grady, NW Bunnett, and EA Mayer. Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors. J. Neurosci. 17: 8129-8136, 1997.

  2. Marvizón, JCG, S. Eskandari, H. Ennes, and EA Mayer. Substance P induces brief, localized increases in [Ca2+]i in dorsal horn neurons. Neuro Report 9 (15): 3369-3374, 1998.

  3. Marvizon, JCG, EF Grady, E. Stefani, NW Bunnett, and EA Mayer. Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABAB receptors. Eur. J. Neurosci. 11: 417-426, 1999.

  4. Marvizón, JCG, EF Grady, J. Wazsak-McGee, and E. Mayer. Internalization of m-opioid receptors in rat spinal cord slices. Neuro Report 10 (11): 2329-2334, 1999.

  5. McRoberts, JA, SV Coutinho, JCG Marvizon, EF Grady, M. Tognett, JN Sengupta, HS Ennes, VV Chaban, S. Amadesi, Ch. Creminon, T. Lanthorn, P. Geppetti, NW Bunnett, and EA Mayer. Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 120: 1737-1748, 2001.

  6. IJ Lever, EJ Bradbury, JR Cunningham, DW Adelson, MG Jones, SB McMahon, JCG Marvizon and M. Malcangio. Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of nociceptor stimulation. J. Neurosci. 21(12): 4469-4477, 2001.

  7. Marvizón, JCG, J. McRoberts, HS Ennes, B. Song, X. Wang, L. Jinton, B. Corneliussen, and EA Mayer. Two NMDA receptors in rat dorsal root ganglia with different subunit composition and localization. J.Comp. Neurol. 446: 325-341, 2002.

  8. Wang, X., and JCG Marvizón. Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons. Brain Res. 944: 239-247, 2002.

  9. Marvizón, JCG, X. Wang, Y. Matsuka, JK Neubert, and I. Spigelman. Relationship between capsaicin-evoked substance P release and NK1 receptor internalization in the rat dorsal horn. Neuroscience 118 (2): 535-545, 2003.

  10. Song, B., and JCG Marvizon. Peptidases prevent m-opioid receptor internalization in dorsal horn neurons by endogenously released opioids. J. Neurosci. 23: 1847-1858, 2003 .

  11. Song, B., and JCG Marvizón. Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce m-opioid receptor internalization in the rat spinal cord. J. Neurosci. 23: 9171-9184, 2003.

  12. Lao, LJ, Song, B. and JCG Marvizón. Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with NMDA and GABAB receptors. Neuroscience 121: 667-680, 2003.

  13. Marvizón, JCG, X. Wang, L. Lao, and B. Song. Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord. Br. J. Pharmacol. 140: 1389-1398, 2003.

  14. Lao L., and JCG Marvizón. GABAA receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord. Neuroscience 130: 1013-1027, 2005.

  15. Kondo, I., JCG Marvizón, B. Song, F. Salgado, S. Codeluppi, X.-Y. Hua and T. Yaksh. Inhibition by spinal m- and d-opioid agonists of afferent-evoked substance P release. J. Neurosci. 25: 3651-3660, 2005.

  16. Cottrell,GS, D. Roosterman, JC Marvizon, B. Song, E. Wick, S. Pikios, H. Wong, C. Berthelier, Y. Tang, C. Sternini, CW Tam, SD Brain, NW Bunnett, E. Grady. Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. J.Comp. Neurol. 490: 235-255, 2005.

  17. Song, B., and JCG Marvizón. NMDA receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce m-opioid receptor internalization in the rat spinal cord. Neuroscience 136: 549-562, 2005.

  18. Bradesi, S. , E. Kokkotou, S. Simeonidis, S. Patierno, HS Ennes, Y. Mittal, JA McRoberts, G. Ohning, JCG Marvizon, C. Sternini, C. Pothoulakis and EA Mayer. The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology 130: 1729-1742, 2006.

  19. Song, B., W. Chen and JCG Marvizon. Inhibition of opioid release in the rat spinal cord by serotonin 5-HT1A receptors. Brain Res. 1158: 57-62, 2007.

  20. Marvizon, JCG, OA Perez, B. Song, W. Chen, NW Bunnett, EF Grady, and AJ Todd. Calcitonin Receptor-Like Receptor and Receptor Activity Modifying Protein 1 in the rat dorsal horn: localization in excitatory presynaptic terminals containing opioids and adrenergic α2C receptors. Neuroscience 148: 250-265, 2007.

  21. Chen, W., B. Song, L. Lao, OA Perez, W. Kim, and JCG Marvizon. Comparing analgesia and µ-opioid receptor internalization produced by intrathecal enkephalin: Requirement for peptidase inhibition. Neuropharmacology 53: 664-667, 2007.

  22. Lao, L., B. Song, W. Chen, and JCG Marvizon. Noxious mechanical stimulation evokes the segmental release of opioid peptides that induces µ-opioid receptor internalization. Brain Res. 1197: 85-93, 2008.

  23. Chen, W., B. Song, G. Zhang, and JCG Marvizon. Effects of veratridine and high potassium on µ-opioid receptor internalization in the rat spinal cord: stimulation of opioid release versus inhibition of internalization. J. Neurosci. Methods 170: 285-293, 2008.

  24. Chen, W., B. Song and JCG Marvizón. Inhibition of opioid release in the rat spinal cord by α2C adrenergic receptors. Neuropharmacology 54: 944-953, 2008.

  25. Chen, W., and JCG Marvizón. Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by µ-opioid receptor internalization. Neuroscience 161: 157-172, 2009.

  26. Adelson, DW, L. Lao, G. Zhang, W. Kim, and JCG Marvizón. Substance P release and neurokinin 1 receptor activation in the rat spinal cord increases with the firing frequency of C-fibers. Neuroscience 161: 538-553, 2009. PMC2692762

  27. Marvizon, JCG, W. Chen, and N. Murphy. Enkephalins, dynorphins and β-endorphin in the rat dorsal horn: an immunofluorescence colocalization study. J.Comp. Neurol. 517: 51-68, 2009. PMC2924145

  28. Zhang G., W. Chen, L. Lao and JCG Marvizon. Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization. Eur. J. Neurosci. 31: 225-237, 2010. PMC2857979

  29. Chen W., G. Zhang and JCG Marvizon. NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord. Neuroscience 166: 924-934, 2010. PMC2837134

  30. Ao Y, M. Ko, A. Chen, JC Marvizon, DW Adelson, MK Song, LW Go, LL Liu, H. Yang. Potent hyperglycemic and hyperinsulinemic effects of thyrotropin-releasing hormone microinjected into the rostroventrolateral medulla and abnormal responses in type 2 diabetic rats. Neuroscience 169: 706-719, 2010. PMC3896326

  31. Chen, W., G. Zhang and JCG Marvizon. Src family kinases mediate the inhibition of substance P release in the spinal cord by µ-opioid receptors and GABAB receptors, but not α2 adrenergic receptors. Eur. J. Neurosci. 32: 963-973, 2010. PMC2942982

  32. McRoberts JA, Ennes H., Marvizon JCG, Fanselow M., Mayer EA, Vissel B. Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test. Neuroscience 172: 474-482, 2011. PMC3010451

  33. Taylor BK, W. Fu, KE Kuphal, C.-O. Stiller, MK Winter, W. Chen, GF Corder, JH Urban, KE McCarson, and JC Marvizon. Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons. Neuroscience 256:178-194, 2014. PMC4363128

  34. Chen W, McRoberts JA, Marvizon JCG. µ-Opioid receptor inhibition of substance P release from primary afferents disappears during neuropathic pain but not inflammatory pain. Neuroscience 267: 67-82, 2014. PMC3998911

  35. Chen W., W. Walwyn, H. Ennes, JA McRoberts, JCG Marvizón. BDNF released by microglia during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur. J. Neurosci. 39: 1439-1454, 2014. PMC4122572

Chronic pain mechanisms (latent sensitization)

  1. Marvizón JC, Walwyn W, Minasayan A, Chen W, Taylor BK. Latent Sensitization: a model for stress-sensitive chronic pain. Current Protocols in Neuroscience 71: 9.50.1-9.50.14, 2015. PMC4532319

  2. Walwyn W., W. Chen, H. Kim, A. Minasayan, H. Ennes, JA McRoberts, JC Marvizón. Sustained suppression of hyperalgesia during latent sensitization by µ, δ and κ opioid receptors and α2A adrenergic receptors - role of constitutive activity. J. Neurosci. 36: 204-221, 2016 . PMC4701961

  3. Chen W., HS Ennes, JA McRoberts, JC Marvizon. Mechanisms of µ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord. Neuropharmacology 128: 255-268, 2018. PMC5726399

  4. Chen W, Tache Y, Marvizon JCG. Corticotropin Releasing Factor in the brain and blocking spinal descending signals induces hyperalgesia in the latent sensitization model of chronic pain. Neuroscience 381: 149-158, 2018. PMC5962032

  5. Severino, A, W Chen, JK Hakimian, B Kieffer, C Gaveriaux-Ruff, W Walwyn, JC Marvizon. Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain. Pain 159: 1607-1620, 2018. PMC6053329  full-text

  6. Marvizon, JC, W Chen, W Fu, and BK Taylor. Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury. Neuropharmacology 158: 107732, 2019.

  7. Chen, W, JC Marvizon. A Src family kinase maintains latent sensitization in rats, a model of inflammatory and neuropathic pain. Brain Res 1746: 146999 (2020). Biorxiv

  8. Chen, W, JC Marvizon. Neurokinin 1 receptor activation in the rat spinal cord maintains latent sensitization, a model of inflammatory and neuropathic chronic pain. Neuropharmacology 177: 108253 (2020 ). Biorxiv

  9. Chen, W, McRoberts JA, Ennes HS, Marvizon JC. cAMP signaling through protein kinase A and Epac2 induces substance P release in the rat spinal cord. Neuropharmacology 189: 108533 (2021) PMC8577816