The runner’s high is an example of endorphin rush, but it is unclear if it is caused by endorphins or endocannabinoids.

Mutations that increase the endocannabinoid anandamide decreased pain, but did not eliminate as completely as mutations in Nav1.7

The endocannabinoids anandamide and 2-AG act as retrograde neurotransmitters in synaptic plasticity and memory formation, anxiety and pain.