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Dopamine D2 Receptor Downregulation Is the Hallmark of Addiction (Dopamine 4)
Dopamine D1 receptors mediate desire. The D2 receptors mediate self-control. Addictive drugs downregulate the D2 receptors, inducing the craving and impulsivity of addiction.
Hermes Solenzol
Nov 14, 202511 min read


The Runner’s High—Endorphin Rush or Endocannabinoids?
The runner’s high is an example of endorphin rush, but it is unclear if it is caused by endorphins or endocannabinoids.
Hermes Solenzol
Nov 2, 202313 min read


Dopamine: Why Heroin Is Addictive but Porn Is Not
Porn is not addictive. It induces short increases of dopamine and not the sustained ones produced by cocaine and opioids.
Hermes Solenzol
Aug 24, 202322 min read
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